Haissi Cui

This paper develops an mRNA-based platform to transiently control sialoglycan biosynthesis on human cells by delivering sialyltransferase enzymes, showing increased surface presentation of specific sialoglycans with minimal off-target effects.

This paper introduces TeACAT, a method to track newly synthesized proteins in mice by incorporating a non-canonical amino acid, enabling visualization and quantification with minimal perturbation.

The paper investigates a disease-causing mutation in IARS1 that affects protein complex formation and the integrated stress response, leading to altered cellular stress responses.

This study shows that sialoglycans on human T cells reduce Fas receptor-mediated apoptosis but not other TNF receptor pathways.

This study identifies a point mutation in SRRM2 as a risk factor for ALS, showing it disrupts protein interactions and dysregulates synapse-related genes.

The paper describes how a volunteer-led affinity group enhances computational biology skills and networking among researchers at an academic institute.

This study shows that RARS1's integration into the multisynthetase complex is essential for normal brain development in mice, as its exclusion leads to developmental defects and gene dysregulation.

This study characterizes T cell glycosylation patterns across mouse and human tissues, revealing species-specific differences in glycan profiles and dynamics.

AARS Online provides a curated database of aminoacyl-tRNA synthetases with sequence, structure, and evolutionary information, accessible via an interactive platform.

The paper shows that arginine depletion during inflammation reduces nuclear ArgRS, which interacts with SRRM2, altering splicing and metabolic outcomes.

The paper shows TyrRS mediates a late integrated stress response by inhibiting translation and protecting cells from prolonged stress through nuclear translocation.