Scott A. Yuzwa

A Metabolic Labeling Strategy for Tracking Protein Synthesis in Complex Biological Systems

This paper introduces TeACAT, a method to track newly synthesized proteins in mice by incorporating a non-canonical amino acid, enabling visualization and quantification with minimal perturbation.

Spatially resolved transcriptomics identifies intercellular signaling post-ischemic stroke that controls neural stem cell proliferation

The paper identifies intercellular signaling pathways post-ischemic stroke that regulate neural stem cell proliferation using spatial transcriptomics and computational analysis.

RARS1 integration into the multisynthetase complex is crucial for mammalian brain development

This study shows that RARS1's integration into the multisynthetase complex is essential for normal brain development in mice, as its exclusion leads to developmental defects and gene dysregulation.

Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells

This study converts postnatal mouse astrocytes to oligodendrocyte lineage cells using Sox10 or Olig2, supported by single-cell RNA sequencing and computational models.

Single cell approaches define forebrain neural stem cell niches and identify microglial ligands that enhance precursor-mediated remyelination

The paper uses single-cell RNA-sequencing and spatial transcriptomics to study forebrain neural stem cell niches and identifies microglial ligands that enhance remyelination.