Author

Han Gao

University of TorontoORCID 0000-0002-7404-2153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Haissi CuiiD· 2 shared Qingyu Shi· 2 shared Rasangi Tennakoon· 2 shared Samuel Protais NyandwiiD· 2 shared Colette Maya MacariosiD· 1 shared Danyon HarkinsiD· 1 shared Felicia Pais AraújoiD· 1 shared Hui PengiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Haissi CuiORCID

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2 papers

Recent·Most cited

A disease-causing Isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response

Han Gao, Rasangi Tennakoon, Felicia Pais Araújo, Jolie M. Miller, Samuel Protais Nyandwi, Qingyu Shi, J. P. Padilla-Martínez, Hui Peng, Haissi Cui

The paper investigates a disease-causing mutation in IARS1 that affects protein complex formation and the integrated stress response, leading to altered cellular stress responses.

Journal of Biological Chemistry · Jan 23, 2026Peer-reviewedMolecular Biology

RARS1 integration into the multisynthetase complex is crucial for mammalian brain development

Samuel Protais Nyandwi, Rasangi Tennakoon, Qingyu Shi, Sofija Volkanoska, Danyon Harkins, Han Gao, Yong Bu, Colette Maya Macarios, Scott A. Yuzwa, Haissi Cui

This study shows that RARS1's integration into the multisynthetase complex is essential for normal brain development in mice, as its exclusion leads to developmental defects and gene dysregulation.

bioRxiv · Sep 8, 2025 · PreprintMolecular Biology