ZCCHC4 Promotes Translation of Replication-dependent Histone mRNAs by Recruiting Cytoplasmic eIF3 complex
Ruiqi Wang, Xiaoyan Shi, Yangyi Zhang, Yuci Wang, Yanlan Cao, Rui Feng, Chen Chen, Yingchun Zhang, Hao Chen, Honghui Ma
This study shows ZCCHC4 promotes translation of replication-dependent histone mRNAs by interacting with the cytoplasmic eIF3 complex, leading to genomic instability and tumor suppression upon its depletion.
bioRxiv · Jun 21, 2025 · PreprintCancer Biology