Author

Yuejin Eugene Yu

Roswell Park Comprehensive Cancer Center

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Physiology· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Organism:mouse· 1 Approach:statistical model· 1

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Christy M NguyeniD· 1 shared Dylan C. SarveriD· 1 shared Fangluo CheniD· 1 shared Guang William WongiD· 1 shared Marcus Michael SeldiniD· 1 shared Muzna Saqib· 1 shared Susan M. Aja· 1 shared

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2026-2026 · peak 1/yr

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Christy M NguyenORCID

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1 paper

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PhysiologyeLifePeer-reviewedJul 22, 2026

✦ In-depth digest

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

Fangluo Chen, Muzna Saqib, Christy M Nguyen…·Guang William Wong

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

1 citation

mousebulk RNA-seq

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