Author

Muzna Saqib

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 3 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Dylan C. SarveriD· 4 shared Guang William WongiD· 4 shared Fangluo CheniD· 3 shared Susan M. Aja· 2 shared Christy M NguyeniD· 1 shared Diya K Mistri· 1 shared Laura Tan· 1 shared Marcus Michael SeldiniD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPhysiology

Dylan C. SarverORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Reduced cerebral blood flow and metabolic rate trigger an adaptive mitochondrial remodeling program in a Down syndrome mouse model

Muzna Saqib, Dylan C. Sarver, Zhiliang Wei, Guang William Wong

In Dp16 Down syndrome mice, MRI shows reduced cerebral blood flow and oxygen metabolism (significant in males), while brain mitochondrial respiratory capacity stays largely intact and oxidative phosphorylation genes rise.

bioRxiv · Oct 31, 2026 · PreprintPhysiology✦ In-depth digest

Deep phenotyping and multi-omics analyses reveal systems-wide metabolic dysregulation in a refined trisomy mouse model of Down syndrome

Muzna Saqib, Fangluo Chen, Diya K Mistri, Laura Tan, Noelle Wright, Dylan C. Sarver, Robert A. Anders, Susan M. Aja, Guang William Wong

The paper compares metabolic dysregulation in two Down syndrome mouse models, finding Ts66Yah exhibits more severe metabolic disturbances than Ts65Dn.

bioRxiv · Aug 29, 2026 · PreprintPhysiology

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

Fangluo Chen, Muzna Saqib, Christy M Nguyen, Dylan C. Sarver, Yuejin Eugene Yu, Susan M. Aja, Marcus Michael Seldin, Guang William Wong

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

eLife · Jul 22, 2026Peer-reviewedPhysiology✦ In-depth digest

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

Dylan C. Sarver, Muzna Saqib, Fangluo Chen, Guang William Wong

The paper creates a mitochondrial respiration atlas across 33 tissues in young and old mice, revealing age and sex effects on mitochondrial function.

eLife · Dec 20, 2024Peer-reviewedSystems Biology