Guang William Wong

Reduced cerebral blood flow and metabolic rate trigger an adaptive mitochondrial remodeling program in a Down syndrome mouse model

In Dp16 Down syndrome mice, MRI shows reduced cerebral blood flow and oxygen metabolism (significant in males), while brain mitochondrial respiratory capacity stays largely intact and oxidative phosphorylation genes rise.

Deep phenotyping and multi-omics analyses reveal systems-wide metabolic dysregulation in a refined trisomy mouse model of Down syndrome

The paper compares metabolic dysregulation in two Down syndrome mouse models, finding Ts66Yah exhibits more severe metabolic disturbances than Ts65Dn.

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

Mid-aged mice rapidly normalize dysglycemia but aggravate obesity-induced hypothalamic and microglial changes upon dietary obesity reversal

This study shows that mid-aged mice normalize dysglycemia faster than young mice when reversing obesity, but their hypothalamic microgliosis worsens after diet reversal.

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

The paper creates a mitochondrial respiration atlas across 33 tissues in young and old mice, revealing age and sex effects on mitochondrial function.

Genomic insights into metabolic flux in ruby-throated hummingbirds

This study presents a genome and transcriptome analysis of ruby-throated hummingbirds, identifying metabolic adaptations related to energy turnover and glucose regulation.

Hepatocyte androgen receptor in females mediates androgen-induced hepatocellular glucose mishandling and systemic insulin resistance

This study shows that deleting the hepatic androgen receptor in female mice prevents androgen-induced insulin resistance and glucose intolerance.

Single molecule, full-length transcript sequencing provides insight into the extreme metabolism of ruby-throated hummingbird Archilochus colubris

The paper uses full-length transcript sequencing to analyze the transcriptome of the ruby-throated hummingbird, revealing sequence divergence in lipid metabolic genes.