Author

Fangluo Chen

Johns Hopkins UniversityORCID 0000-0001-7980-2097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Dylan C. SarveriD· 3 shared Guang William WongiD· 3 shared Muzna Saqib· 3 shared Susan M. Aja· 2 shared Christy M NguyeniD· 1 shared Diya K Mistri· 1 shared Laura Tan· 1 shared Marcus Michael SeldiniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersPhysiology

Dylan C. SarverORCID

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintAug 29, 2026

Deep phenotyping and multi-omics analyses reveal systems-wide metabolic dysregulation in a refined trisomy mouse model of Down syndrome

Muzna Saqib, Fangluo Chen, Diya K Mistri…·Guang William Wong

The paper compares metabolic dysregulation in two Down syndrome mouse models, finding Ts66Yah exhibits more severe metabolic disturbances than Ts65Dn.

DOI 10.64898/2026.08.26.747201

mousebulk RNA-seq

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PhysiologyeLifePeer-reviewedJul 22, 2026

✦ In-depth digest

Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

Fangluo Chen, Muzna Saqib, Christy M Nguyen…·Guang William Wong

Dp16 mice, carrying 115 triplicated Hsa21 orthologs, show sex-shared insulin resistance, glucose intolerance and dyslipidemia, worsened by high-fat diet, with multi-tissue transcriptome and metabolome signatures.

1 citation

mousebulk RNA-seq

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Systems BiologyeLifePeer-reviewedDec 20, 2024

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

Dylan C. Sarver, Muzna Saqib, Fangluo Chen, Guang William Wong

The paper creates a mitochondrial respiration atlas across 33 tissues in young and old mice, revealing age and sex effects on mitochondrial function.

21 citations

mousebulk RNA-seq

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