NEURON-SPECIFIC CHROMOSOMAL MEGADOMAIN ORGANIZATION IS ADAPTIVE TO RECENT RETROTRANSPOSON EXPANSIONS
Sandhya Chandrasekaran, Sergio Espeso‐Gil, Yong‐Hwee Eddie Loh, Behnam Javidfar, Bibi S. Kassim, Yueyan Zhu, Yuan Zhang, Yuhao Dong, Lucy K. Bicks, Haixin Li, Prashanth Rajarajan, Cyril Jayakumar Peter, Daijing Sun, Esperanza Agulló-Pascual, Marina Iskhakova, , Schahram Akbarian
The paper shows that neuron-specific chromatin domains in mice are shaped by recent retrotransposon expansions and that disrupting a silencer leads to chromatin rewiring and neuroinflammation.
Nature Communications · Dec 13, 2021Peer-reviewedNeuroscience