Author
Icahn School of Medicine at Mount SinaiORCID 0000-0003-1730-293XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Amara L. Plaza-Jennings, Aditi Valada, Callan P. O’Shea…·Schahram Akbarian
The paper examines HIV integration in the human brain using single nuclei transcriptomics, Hi-C, and IS-seq, finding 3D genomic reorganization and microglial activation linked to HIV infection.
Sandhya Chandrasekaran, Sergio Espeso‐Gil, Yong‐Hwee Eddie Loh…·Schahram Akbarian
The paper shows that neuron-specific chromatin domains in mice are shaped by recent retrotransposon expansions and that disrupting a silencer leads to chromatin rewiring and neuroinflammation.
Sergio Espeso‐Gil, Aliaksei Z. Holik, Sarah Bonnin…·Stephan Ossowski
This study shows environmental enrichment alters chromatin structure, transcription factor binding, and 3D genome organization in mice, affecting cognitive function and gene regulation.