Yong‐Hwee Eddie Loh

The paper shows that peri/centromeric regions in ape genomes are hypomethylated CpG reservoirs, linking germline hypomethylation to CpG evolution and structural transcriptomic innovation.

The paper produces gapless assemblies of ape sex chromosomes for five great apes and a lesser ape, revealing divergence in Y chromosomes and evolutionary dynamics.

The paper constructs a gene regulatory network (GRN) for alveologenesis in a mouse model of BPD, revealing how IGF1 signaling regulates lung development and identifies potential therapeutic targets.

The paper shows that neuron-specific chromatin domains in mice are shaped by recent retrotransposon expansions and that disrupting a silencer leads to chromatin rewiring and neuroinflammation.

This study identifies Brg1's role in specifying neurosensory lineage and differentiation in the mammalian inner ear by interacting with Eya1/Six1 and regulating chromatin structure.

The paper identifies Zfp189 as a key driver of a transcriptional network promoting stress resilience in prefrontal cortex neurons through CREB regulation.