Author

Yuichi Aki

Princeton University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Christopher J. ChangiD· 2 shared Jaehee KimiD· 2 shared Aidan T. PezackiiD· 1 shared Andreas StahliD· 1 shared Chang JiangiD· 1 shared David Li· 1 shared Diyala S. ShihadihiD· 1 shared Dominic SantoleriiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPhysiology

Christopher J. ChangORCID

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2 papers

Recent·Most cited

A Liver-Targeted Copper Supplement Reduces Metabolic Dysfunction-Associated Liver Steatosis by Increasing Lipolysis and Fatty Acid Oxidation

Jaehee Kim, Vanha N. Pham, Timothy A. Su, Irene Liparulo, Diyala S. Shihadih, Tong Xiao, Xiao Xie, Yuichi Aki, Aidan T. Pezacki, Wendy Cao, James A. Olzmann, Joshua D. Rabinowitz, Andreas Stahl, Christopher J. Chang

The paper shows liver-targeted copper supplementation reduces steatosis by enhancing lipolysis and fatty acid oxidation through copper-dependent metabolic pathways.

bioRxiv · May 20, 2026 · PreprintPhysiology

Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency

Jaclyn E. Welles, James P. Garifallou, Michael V. Gonzalez, Dominic Santoleri, Feroza K. Choudhury, Gina M. DeNicola, Ryan W. Martin, Chang Jiang, Jaehee Kim, Gen Li, Yuichi Aki, Christopher J. Chang, David Li, Rebecca G. Wells, Yang Xiao, , Paul M. Titchenell

This study shows that reduced hepatic phosphatidylcholine biosynthesis leads to copper deficiency, which promotes MASH through disrupted copper distribution and fibrogenesis.

bioRxiv · May 14, 2026 · PreprintPhysiology