Yujie Qiao

Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients

The paper identifies distinct CD8+ T-cell types associated with mild versus severe COVID-19 in unvaccinated HLA-A2+ patients, showing protective immunity correlates with specific cell subsets.

Immortalized AT2 Cell Lines from Healthy and IPF Lungs Enable 2D and 3D Cultures

The paper generates immortalized AT2 cell lines from healthy and IPF lungs that maintain key biological features in 2D and 3D cultures, providing a platform for lung disease research.

NanoHIVSeq: A Long-Read Bioinformatics Pipeline for High-Throughput Processing of HIV Env Sequences

NanoHIVSeq is a UMI-free pipeline for processing HIV Env sequences from ONT data, achieving high accuracy and efficiency in variant recovery.

Phosphatidylcholine Metabolism Controls Alveolar Progenitor Renewal and Pulmonary Fibrosis

This study identifies LPCAT1 as a critical regulator of AT2 cell renewal and lipid metabolism in IPF, showing that reactivating LPCAT1 can mitigate lung fibrosis.

Activation of the impaired NAMPT/SIRT7/SOD2 axis restores alveolar progenitor cell homeostasis in idiopathic pulmonary fibrosis and reverses pulmonary fibrosis in mice

This study identifies NAMPT as a key regulator of alveolar progenitor cell function in IPF, showing that its activation restores homeostasis and reverses fibrosis in mice.