Author

Lucas F. Loffredo

Columbia UniversityORCID 0000-0002-0835-6496Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Kenia de los SantosiD· 2 shared Nicholas ArpaiaiD· 2 shared Adam E. KornbergiD· 1 shared Anjali SaqiiD· 1 shared Anmol Kustagi· 1 shared Arnold S. HaniD· 1 shared Christine Groso· 1 shared Christopher L. RicuperoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

Kenia de los SantosORCID

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Author profile →

3 papers

Recent·Most cited

Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients

Kazuya Masuda, Sho Iketani, Lihong Liu, Jing Huang, Yujie Qiao, Jayesh Shah, Meredith McNairy, Christine Groso, Christopher L. Ricupero, Lucas F. Loffredo, Qian Wang, Lawrence J. Purpura, Jordana Grazziela Alves Coelho-dos-Reis, Zizhang Sheng, Michael T. Yin, Moriya Tsuji

The paper identifies distinct CD8+ T-cell types associated with mild versus severe COVID-19 in unvaccinated HLA-A2+ patients, showing protective immunity correlates with specific cell subsets.

bioRxiv · Jun 19, 2026Immunology

An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Treg cells

Lucas F. Loffredo, Katherine A. Kaiser, Adam E. Kornberg, Samhita Rao, Kenia de los Santos, Arnold S. Han, Nicholas Arpaia

The paper develops an Areg reporter mouse to study Treg cell transcriptional and clonal expansion in lung repair, identifying 4-1BB agonism as a novel reparative mechanism.

JCI Insight · Jul 7, 2025Peer-reviewedImmunology

Heparan sulfate regulates amphiregulin signaling towards reparative lung mesenchymal cells during influenza A infection

Lucas F. Loffredo, Anmol Kustagi, Olivia Rose Ringham, Fangda Li, Kenia de los Santos, Anjali Saqi, Nicholas Arpaia

This study shows heparan sulfate is essential for Areg signaling in lung mesenchymal cells during influenza A infection, affecting reparative responses.

Nature Communications · Mar 3, 2025Peer-reviewedImmunology