Yue Hu

Contributions of Folded and Disordered Domains to RNA Binding by HNRNPR

This study identifies RNA binding domains in HNRNPR, showing that RRM3 and a C-terminal charged region are critical for RNA binding, and reveals specific interactions with G-quadruplexes.

Massively parallel characterization of RNA G-quadruplex stability and molecular recognition

The paper characterizes RNA G-quadruplex stability and recognition by ligands and proteins using a synthetic library and reverse-transcriptase stop sequencing.

Sequence and structure of protein binding sites in RNA impact biomolecular condensates

The paper investigates how RNA-protein binding site context, not just valence, affects biomolecular condensate properties in Ashbya gossypii.

Dissecting RNA Selectivity Mediated by Tandem RNA-Binding Domains

The paper investigates how tandem RNA-binding domains in three proteins mediate RNA selectivity through in vitro assays and in vivo validation, showing that intrinsic specificities and cellular context influence target discrimination.

A foundation language model to decipher diverse regulation of RNAs

The paper introduces LAMAR, a transformer-based foundation language model for RNA regulation, which outperforms state-of-the-art methods in predicting mRNA translation efficiency and half-life.

A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation

The paper systematically identifies PRMT interactomes and shows arginine methylation regulates RNA splicing and translation by affecting ribosome assembly and cell growth.