Modelling medulloblastoma pathogenesis and treatment in human cerebellar organoids.
Thomas Willott, James G Nicholson, Yunchen Xiao, Olumide Kayode Ogunbiyi, Benjamin Draper, Talisa Mistry, Laura Donovan, Nicolae Radu Zabet, Ashirwad Merve, Sara Badodi, Silvia Marino
This study generates human cerebellar organoids to model medulloblastoma subgroups G3 and G4, showing their ability to sustain tumor growth and respond to anti-tumour compounds.
bioRxiv · Aug 14, 2024 · PreprintCancer Biology