TRiC folds the giant ciliary protein IFT172 via a non-canonical open-state mechanism
Qiaoyu Zhao, Jiayi Li, Yujie Tong, Yurui Li, Wenyu Han, Zuyang Li, yanxing wang, Yue Yin, Jun Fang, Wanying Jiang, Qianqian Song, Shengyou Huang, Yidong Shen, Yao Cong
This study reveals how TRiC folds the large ciliary protein IFT172 using a non-canonical open-state mechanism involving Z-shaped bending and fold-and-eject dynamics.
bioRxiv · Mar 31, 2026 · PreprintBiochemistry