Author

Junichiro Ishikawa

The University of TokyoORCID 0000-0003-4112-4168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Assay:structural biology· 1

Frequent Co-Authors

Hiroshi NishimasuiD· 3 shared Kanta YoneyamaiD· 2 shared Keitaro YamashitaiD· 2 shared Masahiro HiraizumiiD· 2 shared Cian Schmitt-UlmsiD· 1 shared Dennis J. ZhangiD· 1 shared Erick Helmeczi· 1 shared Eugene V. KooniniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

Hiroshi NishimasuORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyCellPeer-reviewedJul 28, 2026

Coordinated RNA- and protein-templated synthesis ofdouble-stranded DNA by a dual reverse transcriptase immune system

Megan Wang, Kanta Yoneyama, Rimantė Žedaveinytė…·Samuel H. Sternberg

The paper shows how two reverse transcriptases with different templating strategies work together to produce complementary DNA for antiviral defense.

1 citation

DNA methylationexperimental assay

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BiochemistrybioRxivPreprintJul 15, 2026

Structural mechanism of the type IX Retron-Kva2 anti-phage defense system

Yuya Hayashi, Yoshihisa Mitsuda, Kotaro Chihara…·Hiroshi Nishimasu

This study reveals the structural mechanism of the type IX Retron-Kva2 anti-phage defense system in Klebsiella variicola, showing how it cleaves host RNAs to inhibit phage infection.

2 citations

bacteria (other)structural biology

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Molecular BiologybioRxivPreprintAug 17, 2022

RNA-triggered protein cleavage and cell death by the RNA-guided type III-E CRISPR-Cas nuclease-protease complex

Kazuki Kato, Sae Okazaki, Cian Schmitt-Ulms…·Hiroshi Nishimasu

This study characterizes the RNA-guided nuclease-protease complex Cas7-11-Csx29, showing target RNA binding activates Csx29 to cleave Csx30, leading to cell death.

4 citations

experimental assay

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