Hepatocellular carcinoma-associated AXIN1 mutations drive low levels of Wnt/β-catenin pathway activity that allow for niche-independent growth and YAP/TAZ signaling
Anton Jan Venhuizen, Yvanka van Os, Milo L. Kaptein, Marleen T. Aarts, Despina Xanthakis, Ingrid Jordens, Madelon M. Maurice
This study shows that AXIN1 mutations in HCC lead to reduced Wnt/β-catenin activity and increased YAP/TAZ signaling, enabling niche-independent growth.
iScience · Dec 20, 2025Peer-reviewedCancer Biology