Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression
Z. A. Lopez-Bujanda, M. C. Haffner, M. G. Chaimowitz, N. Chowdhury, N. J. Venturini, A. Obradovic, C. S. Hansen, J. Jackow, K. S. Sfanos, C. J. Bieberich, P. J. Hurley, M. J. Selby, A. J. Korman, A. M. Christiano, A. M. De Marzo, C. G. Drake
This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.
bioRxiv · May 27, 2019Immunology