Author

M. G. Chaimowitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. G. Drake· 2 shared A. Califano· 1 shared A. J. Korman· 1 shared A. M. Christiano· 1 shared A. M. De Marzo· 1 shared A. Obradovic· 1 shared A. Z. Obradovic· 1 shared C. B. Anderson· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

C. G. Drake

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2 papers

Recent·Most cited

Single-Cell RNAseq Analysis Reveals Robust Anti-PD-1-Mediated Increase of Immune Infiltrate in Metastatic Castration-Sensitive Prostate Cancer

J. E. Hawley, A. Z. Obradovic, M. C. Dallos, E. A. Lim, K. Runcie, C. R. Ager, J. M. McKiernan, C. B. Anderson, G. J. Decastro, J. L. Weintraub, R. K. Virk, I. Lowy, J. Hu, M. G. Chaimowitz, X. V. Guo, , C. G. Drake

The paper analyzes single-cell RNAseq data from metastatic castration-sensitive prostate cancer patients treated with anti-PD-1 immunotherapy, showing increased immune infiltrate and identifying therapy-resistant tumor subpopulations and druggable targets.

bioRxiv · May 6, 2022 · PreprintCancer Biology

Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

Z. A. Lopez-Bujanda, M. C. Haffner, M. G. Chaimowitz, N. Chowdhury, N. J. Venturini, A. Obradovic, C. S. Hansen, J. Jackow, K. S. Sfanos, C. J. Bieberich, P. J. Hurley, M. J. Selby, A. J. Korman, A. M. Christiano, A. M. De Marzo, C. G. Drake

This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.

bioRxiv · May 27, 2019Immunology