Functional Communication between IP3R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE
M. Ahmad, H. L. Ong, H. Saadi, G.-Y. Son, Z. Shokatian, L. E. Terry, M. Trebak, D. I. Yule, I. Ambudkar
This study identifies IP3R-mediated local [Ca2+]ER decreases as the driver of immobile STIM2 clusters at ER-PM junctions, marking a checkpoint for SOCE initiation under sub-threshold stimuli.
bioRxiv · Sep 24, 2021 · PreprintPhysiology