Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification
Pratik Koirala, Ziyu Chen, Samerender Nagam Hanumantharao, Ashley Emily Siegel, Chang Liu, Zachary Williams, Harshaan Sekhon, David E. Maridas, Yuji M. Mishina, Vicki Rosen, Shailesh Agarwal
This study identifies rosiglitazone, a PPARγ agonist, as a potential therapy for fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification by converting ectopic bone to fat.
bioRxiv · Mar 16, 2026 · PreprintCell Biology