Vicki Rosen

Paracrine Action of Bone Morphogenetic Protein 3 in Pulmonary Arterial Hypertension

This study shows that BMP3 overexpression reduces pulmonary vascular remodeling and cardiac dysfunction in PAH by balancing TGF-β and BMP pathways through paracrine signaling.

A closed-loop cell therapy engineered to autonomously secrete Activin A inhibitor protects from fibrodysplasia ossificans progressiva

This paper develops a closed-loop cell therapy that secretes an Activin A inhibitor to prevent heterotopic bone formation in a mouse model of FOP.

Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification

This study identifies rosiglitazone, a PPARγ agonist, as a potential therapy for fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification by converting ectopic bone to fat.

Targeting the Alk4 pathway protects against age-related bone loss.

This study shows inhibiting the Alk4 pathway in aging mice prevents age-related bone loss and sarcopenia by reducing Activin signaling.

Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk

The paper investigates regulatory interactions at the GDF5 locus, showing that epistasis between variants, rather than individual variants, influences disease risk and joint morphology.