David E. Maridas

This study shows that high-fat diets during adolescence shift energy allocation in mice toward reproduction, affecting skeletal and metabolic health differently in males and females.

This paper develops a closed-loop cell therapy that secretes an Activin A inhibitor to prevent heterotopic bone formation in a mouse model of FOP.

This study identifies rosiglitazone, a PPARγ agonist, as a potential therapy for fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification by converting ectopic bone to fat.

This study shows inhibiting the Alk4 pathway in aging mice prevents age-related bone loss and sarcopenia by reducing Activin signaling.

The paper investigates regulatory interactions at the GDF5 locus, showing that epistasis between variants, rather than individual variants, influences disease risk and joint morphology.