Yuji M. Mishina

This paper identifies BMP signaling as a driver of heterotopic ossification by promoting ciliogenesis and establishing a sensitized signaling hub that facilitates osteochondrogenic differentiation.

This paper develops a closed-loop cell therapy that secretes an Activin A inhibitor to prevent heterotopic bone formation in a mouse model of FOP.

This study shows BMP signaling induces X-inactivation and promotes chondrogenesis in both sexes by suppressing X-linked genes like Tmsb4x.

This study identifies rosiglitazone, a PPARγ agonist, as a potential therapy for fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification by converting ectopic bone to fat.

The paper identifies a lipid metabolism defect as a contributor to variable anemia in Diamond Blackfan anemia syndrome using a murine model and transcriptomic analysis.

This study identifies defective mesenchymal Bmpr1a-mediated BMP signaling as a cause of congenital pulmonary cysts by disrupting lung branching morphogenesis and airway structure.

This study shows that ALK3-BMP signaling in tongue mesenchyme is essential for taste papilla cell differentiation by regulating secretory proteins and Wnt/β-catenin activity.