Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer
Inga-Maria P. Launonen, Iga Niemiec, María Mercedes Hincapié-Otero, Erdoğan Pekcan Erkan, Ada Junquera, Daria Afenteva, Matías Marín Falco, Zhihan Liang, Matilda Salko, Foteini Chamchougia, Angela Szabo, Fernando Pérez‐Villatoro, Yilin Li, Giulia Micoli, Ashwini Sakrepatna Nagaraj, , Anniina Färkkilä
This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.
Cancer Cell · Dec 1, 2024Peer-reviewedCancer Biology