Author

Fernando Pérez‐Villatoro

University of HelsinkiORCID 0000-0002-5419-8484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Organism:human· 2 Assay:imaging· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Ada JunqueraiD· 3 shared Anni VirtaneniD· 3 shared Anniina FärkkiläiD· 3 shared Angela Szabo· 2 shared Anna VähärautioiD· 2 shared Ella AnttilaiD· 2 shared Essi KaheliniD· 2 shared Foteini ChamchougiaiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Ada JunqueraORCID

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3 papers

Recent·Most cited

Single-cell spatial atlas of high-grade serous ovarian cancer unveils MHC class II as a key driver of spatial tumor ecosystems and clinical outcomes

Fernando Pérez‐Villatoro, Aleksandra Shabanova, Lilian van Wagensveld, Ada Junquera, Iga Niemiec, María Mercedes Hincapié-Otero, Ziqi Kang, Matías Marín Falco, Kürşat Birgin, Sarah Wolf, Ella Anttila, Gayani Anandagoda, Julia Casado, Eric Marcus, Duco Gaillard, , Anniina Färkkilä

Cyclic immunofluorescence of 265 high-grade serous ovarian carcinomas and random-forest feature ranking identify cancer-cell MHC-II as an adjusted predictor of longer survival marking immune-activated tumor-stroma hotspots.

Cancer Discovery · Feb 9, 2026Peer-reviewedCancer Biology✦ In-depth digest

Tribus: Semi-automated discovery of cell identities and phenotypes from multiplexed imaging and proteomicdata

Ziqi Kang, Angela Szabo, Teodora Farago, Fernando Pérez‐Villatoro, Ada Junquera, Shah Saundarya, Inga-Maria P. Launonen, Ella Anttila, Julia Casado, Kevin Meyer Elias, Anni Virtanen, Ulla‐Maija Haltia, Anniina Färkkilä

Tribus is a semi-automated tool for cell phenotyping from multiplexed imaging and proteomic data, achieving high accuracy and efficiency compared to existing methods.

Bioinformatics · Feb 19, 2025Peer-reviewedBioinformatics

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

Inga-Maria P. Launonen, Iga Niemiec, María Mercedes Hincapié-Otero, Erdoğan Pekcan Erkan, Ada Junquera, Daria Afenteva, Matías Marín Falco, Zhihan Liang, Matilda Salko, Foteini Chamchougia, Angela Szabo, Fernando Pérez‐Villatoro, Yilin Li, Giulia Micoli, Ashwini Sakrepatna Nagaraj, , Anniina Färkkilä

This study shows chemotherapy causes myeloid-driven spatial T-cell exhaustion in ovarian cancer by altering immune cell states and interactions, suggesting new immunotherapy approaches.

Cancer Cell · Dec 1, 2024Peer-reviewedCancer Biology