Programmable conjugative CRISPR interference targeting genotoxin in the gut
Brian Hamp, Hania Timek, Chengyuan Fang, Amber E. Haley, Maria Jennings, Collins I. Chimezie, Noah Hutchinson, Zhihong Dong, Shannon McCollum, Saleh Khawaled, Yatrik Madhukar Shah, Ömer H. Yilmaz, Jiahe Li
This paper develops a CRISPRi system to suppress colibactin production in pks E. coli, reducing DNA damage and tumorigenesis in mice.
bioRxiv · Oct 13, 2025 · PreprintBioengineering