Author

Maria Jennings

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jiahe LiiD· 3 shared Chengyuan FangiD· 2 shared Hania Timek· 2 shared Ningyuan Ye· 2 shared Noah T. HutchinsoniD· 2 shared Amber E. Haley· 1 shared Brian Hamp· 1 shared Collins I. Chimezie· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

Jiahe LiORCID

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Author profile →

3 papers

Recent·Most cited

Engineered Lactate Catabolizing Probiotics Reveal Timescale Dependent Microbiome-Host Metabolic Coupling

Noah T. Hutchinson, Ningyuan Ye, Maria Jennings, Chengyuan Fang, Nathan Qi, Jiahe Li

This paper shows that engineered probiotics converting lactate to pyruvate acutely alter microbiota and host metabolism but fail to improve chronic obesity, highlighting homeostatic limits of gut-targeted therapies.

bioRxiv · Apr 8, 2026 · PreprintMicrobiology

Programmable conjugative CRISPR interference targeting genotoxin in the gut

Brian Hamp, Hania Timek, Chengyuan Fang, Amber E. Haley, Maria Jennings, Collins I. Chimezie, Noah Hutchinson, Zhihong Dong, Shannon McCollum, Saleh Khawaled, Yatrik Madhukar Shah, Ömer H. Yilmaz, Jiahe Li

This paper develops a CRISPRi system to suppress colibactin production in pks E. coli, reducing DNA damage and tumorigenesis in mice.

bioRxiv · Oct 13, 2025 · PreprintBioengineering

Engineered Bacillus subtilis as oral probiotics to enhance clearance of blood lactate

Mengdi Yang, Noah T. Hutchinson, Ningyuan Ye, Hania Timek, Maria Jennings, Jianing Yin, Ming Guan, Zongqi Wang, Peiru Chen, Shaobo Yang, Justin D. Crane, Ke Zhang, Xuesong He, Jiahe Li

This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.

ACS Synthetic Biology · Dec 31, 2024Peer-reviewedSynthetic Biology