Saleh Khawaled

This study identifies polyamines as key regulators of epithelial regeneration in aged intestines, showing they enhance protein homeostasis and restore regenerative capacity through dietary manipulation.

This paper develops a CRISPRi system to suppress colibactin production in pks E. coli, reducing DNA damage and tumorigenesis in mice.

This study identifies SREBP2 as a direct APC-AXIN1 substrate degraded via a β-catenin-independent pathway, regulating cholesterol metabolism and providing a target for APC-mutant colorectal cancer.

This study shows that PPARγ downregulation in colonic CD8+ T cells of people with HIV on ART leads to epithelial barrier disruption by promoting lipid uptake and apoptosis.

This study compares droplet-based and picowell-based single-cell RNA sequencing platforms for human colon biopsies, finding differences in cell recovery, typeability, and gene expression consistency.