A stress-induced Tyrosine tRNA depletion response mediates codon-based translational repression and growth suppression
Doowon Huh, Maria C. Passarelli, Jenny Gao, Shahnoza N Dusmatova, Clara Goin, Lisa Fish, Alexandra M. Pinzaru, Henrik Molina, Zhiji Ren, Elizabeth A. McMillan, Hosseinali Asgharian, Hani Goodarzi, Sohail F. Tavazoie
The paper shows oxidative stress causes tyrosine tRNA fragmentation, leading to translational repression and growth suppression through depletion of the precursor tRNA and inhibition of transcript destabilization.
The EMBO Journal · Dec 21, 2020Peer-reviewedMolecular Biology