Sohail F. Tavazoie

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses

This study shows that colorectal cancers with different metastatic potential trigger distinct early T cell responses, with non-metastatic tumors inducing cytotoxic T cells and pro-metastatic tumors causing hypoactivated T cells.

Tumor Genotype Dictates Mitochondrial and Immune Vulnerabilities in Liver Cancer

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis

The paper identifies ZZEF1 as a tRNA-specific transcription factor that suppresses breast cancer metastasis by regulating tRNA-LysUUU expression and affecting codon-specific translation.

Neuronal substance-P drives breast cancer growth and metastasis via an extracellular RNA/TLR7 axis

This study identifies neuronal substance-P as a driver of breast cancer growth and metastasis through an extracellular RNA/TLR7 signaling axis, with therapeutic targeting showing efficacy in mouse models.

Inter-organellar nucleic acid communication by a mitochondrial tRNA regulates nuclear metabolic transcription

The paper identifies mitochondrial tRNAs in human cell nuclei and shows they regulate nuclear gene expression through interactions with NARS2 and HDAC2, affecting metabolic processes and tumor growth.

A stress-induced Tyrosine tRNA depletion response mediates codon-based translational repression and growth suppression

The paper shows oxidative stress causes tyrosine tRNA fragmentation, leading to translational repression and growth suppression through depletion of the precursor tRNA and inhibition of transcript destabilization.