Molecular BiologyThe EMBO JournalPeer-reviewed
A stress-induced Tyrosine tRNA depletion response mediates codon-based translational repression and growth suppression
Doowon Huh, Maria C. Passarelli, Jenny Gao…·Sohail F. Tavazoie
The paper shows oxidative stress causes tyrosine tRNA fragmentation, leading to translational repression and growth suppression through depletion of the precursor tRNA and inhibition of transcript destabilization.
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