A genetically encoded ionic-stress sensor reveals protons as a sleep driver
Zhijian Ji, Junqiang Liu, Bingying Wang, Shuaian Wei, Yanchang Bian, Wenjie Zeng, Chan-I Chung, Zhimin Ma, Jianxiu Zhang, Xiaokun Shu, K. Dengke
The paper introduces GENTIS, a genetically encoded ionic-stress sensor, and shows that proton accumulation drives sleep in C. elegans through v-ATPase inhibition and membrane disassembly.
bioRxiv · Jan 30, 2026 · PreprintAnimal Behavior & Cognition