Reconstructing donor genotypes from scRNA-seq for downstream eQTL and HLA-TCR analysis
Hannah Kockelbergh, Jennifer Astley, Katherine M. Kichula, Zhipeng Zhang, Esther S. Ng, Calliope Athena Dendrou, Amanda Yoon-Yee Chong, Robert A. Watson, Benjamin Peter Fairfax, Julian Charles Knight, Gavin Band, Paul J. Norman, Mary N Carrington, Stephen Nicholas Sansom, Alexander J. Mentzer, , Yang Luo
This paper introduces scTAPAS, a method to reconstruct donor genotypes from scRNA-seq data, enabling eQTL and HLA-TCR analysis without conventional genotyping.
bioRxiv · Oct 5, 2026 · PreprintBioinformatics