Author

Jennifer Astley

University of OxfordORCID 0009-0004-6502-3788Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:eQTL / molecular QTL mapping· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Approach:matrix factorization· 1

Frequent Co-Authors

Alexander J. MentzeriD· 2 shared Calliope Athena DendrouiD· 2 shared Julian Charles KnightiD· 2 shared Luke Jostins-DeaniD· 2 shared Yang LuoiD· 2 shared Amanda Yoon-Yee ChongiD· 1 shared Andrew John KwokiD· 1 shared Benjamin Hollis· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioinformatics

Alexander J. MentzerORCID

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2 papers

Recent·Most cited

Reconstructing donor genotypes from scRNA-seq for downstream eQTL and HLA-TCR analysis

Hannah Kockelbergh, Jennifer Astley, Katherine M. Kichula, Zhipeng Zhang, Esther S. Ng, Calliope Athena Dendrou, Amanda Yoon-Yee Chong, Robert A. Watson, Benjamin Peter Fairfax, Julian Charles Knight, Gavin Band, Paul J. Norman, Mary N Carrington, Stephen Nicholas Sansom, Alexander J. Mentzer, , Yang Luo

This paper introduces scTAPAS, a method to reconstruct donor genotypes from scRNA-seq data, enabling eQTL and HLA-TCR analysis without conventional genotyping.

bioRxiv · Oct 5, 2026 · PreprintBioinformatics

Single-cell eQTL mapping identifies disease-specific genetic control of COVID-19 infection

Jennifer Astley, Andrew John Kwok, Benjamin Hollis, Calliope Athena Dendrou, Steve C Sansom, Julian Charles Knight, Alexander J. Mentzer, Yang Luo, Luke Jostins-Dean

The paper identifies disease-specific genetic regulation of gene expression in immune cells during COVID-19 infection using single-cell eQTL mapping.

medRxiv · Jun 30, 2025 · PreprintGenetic & Genomic Medicine