Dual DNA-binding capability of Cdc13 coordinates with Ku to safeguard telomere integrity
Zhitong Feng, Jiangchuan Shen, Yuxi Li, Giovanni González-Gutiérrez, Quan Wang, Hengyao Niu
This study shows that Cdc13's dual DNA-binding capability coordinates with Ku to protect telomeres, and mutations in this function lead to metabolic reprogramming and increased fitness in yeast.
bioRxiv · Sep 2, 2025 · PreprintBiochemistry