Author

Zhongqi Hou

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adeline L. VanderveriD· 2 shared Julia Liao HackeriD· 2 shared Sunetra Sase· 2 shared Akshata Almad· 1 shared Alyssa L. GagneiD· 1 shared Amaliris GuerraiD· 1 shared Anjali Bhagavatula· 1 shared Aoife M. Roche· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Adeline L. VanderverORCID

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2 papers

Recent·Most cited

Deletion of TUBB4A mitigates the oligodendrocyte and neuronal deficits in human iPSCs derived from individuals affected by H-ABC

Zhongqi Hou, Rolf Dale Bates, Prabhat R. Napit, Luis Garcia, Anjali Bhagavatula, Julia Liao Hacker, Teshawn Johnson, Alyssa L. Gagne, Jean Ann Maguire, Asako Takanohashi, Deborah L. French, Akshata Almad, Judith B. Grinspan, Adeline L. Vanderver, Sunetra Sase

This study shows that deleting TUBB4A in human iPSCs reduces cell-autonomous deficits in oligodendrocytes and neurons associated with H-ABC, suggesting it could be a therapeutic strategy for TUBB4A-related leukodystrophy.

bioRxiv · Aug 6, 2026 · PreprintNeuroscience

Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Lucas Tricoli, Sunetra Sase, Julia Liao Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife M. Roche, , Stefano Rivella

This paper develops a novel lentiviral vector for gene therapy of MLD that achieves high ARSA activity with minimal genomic integrations, improving safety and efficacy in preclinical models.

Molecular Therapy — Nucleic Acids · Jan 25, 2025Peer-reviewedMolecular Biology