A Unifying Mechanism for Synaptic Amyloid beta Toxicity Beta Adrenergic Potentiation of the Ca2+ Channel CaV1.2 by Amyloid beta
Peter H. Bartels, Sarah L. S. Rougé, James D. Scripter, Zhuoer Zeng, Zoila M. Estrada‐Tobar, Jennifer Price, Ariel A. Jacobi, Ruben A. Berumen, Sheng‐Yang Ho, Andranik Avedisyan, Yang K. Xiang, Chao-Yin Chen, Madeline Nieves‐Cintrón, Manuel F. Navedo, Mary C. Horne, , Johannes W. Hell
This paper identifies a mechanism by which amyloid beta potentiates CaV1.2 channels via β2AR, leading to synaptic dysfunction and neurotoxicity, and shows that disrupting this pathway prevents these effects.
bioRxiv · Apr 29, 2026 · PreprintNeuroscience