Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1
Taoling Zeng, Tingting Jiang, Baoding Zhang, Ting Zhang, Wanjun Dai, Xun Yin, Yunzhan Li, Zhuoran Yu, Caiming Wu, Yaying Wu, Ximin Chi, Xianming Deng, Hongrui Wang
This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.
Acta Pharmaceutica Sinica B · Jul 25, 2025Peer-reviewedCancer Biology