Author

Hongrui Wang

Xiamen UniversityORCID 0000-0002-2916-8849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Taoling ZengiD· 2 shared Baoding ZhangiD· 1 shared Bing XuiD· 1 shared Bowen HouiD· 1 shared Caiming WuiD· 1 shared Changchun XiaoiD· 1 shared Chaonan Yan· 1 shared Chenghao HuangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Taoling ZengORCID

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2 papers

Recent·Most cited

Cancer BiologyActa Pharmaceutica Sinica BPeer-reviewedJul 25, 2025

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

Taoling Zeng, Tingting Jiang, Baoding Zhang…·Hongrui Wang

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

4 citations

humanproteomics

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 17, 2025

Themis dominates T cell exhaustion by regulation of TCR and PD-1 signaling

Jian Tang, Xian Jia, Taoling Zeng…·Guo Fu

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky