Hui Yang

This study identifies RIPK1 activation as a key determinant of response to SMAC mimetics in TNBC, showing that resistance is linked to impaired RIPK1 autophosphorylation and HOIP overexpression.

DS5 is an open-source framework that standardizes HTS data storage, analysis, and drug prioritization, validated against public benchmarks and applied in clinical settings.

This study shows that non-phosphorylated α-synuclein drives Parkinson's disease-like pathogenesis in mice, contradicting the traditional view that phosphorylated α-synuclein is pathogenic.