Flavia Hodel

Comparative evaluation of genotyping and low-pass sequencing for pharmacogenetic variant and phenotype inference

This study compares genotyping arrays and low-pass whole-genome sequencing for pharmacogenetic variant and phenotype inference, finding high concordance but improved variant coverage with LP-WGS.

Rare variants in infection response protein pathways associated with sepsis in children.

The paper identifies genetic pathways and variants associated with sepsis susceptibility in children through genomic analysis of a paediatric cohort.

Associations of genetic and infectious risk factors with coronary heart disease

This study identifies high polygenic risk and infection with Fusobacterium nucleatum as independent risk factors for incident coronary heart disease in a population cohort.

A Comprehensive Assessment of Demographic, Environmental and Host Genetic Associations with Gut Microbiome Diversity in Healthy Individuals

This study identifies non-genetic factors associated with gut microbiome diversity in a cohort of healthy individuals, finding no genome-wide significant genetic associations.

Predicting the occurrence of variants in RAG1 and RAG2

The paper predicts clinically relevant variants in RAG1 and RAG2 by analyzing mutation rates and residue frequencies to identify disease-causing mutations.

Genetic factors and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

This study identifies age, sex, and genetic variants as key predictors of variability in humoral immune responses to pathogens and vaccines.