Naohisa Miyakawa

This study longitudinally assesses DREADD expression and efficacy in macaque monkeys using PET imaging and functional studies, showing peak expression at 60 days and sustained effects for two years.

This study shows that visual category learning enhances category separability in monkey inferior temporal cortex by increasing category-selective neurons and prolonging their responses.

This study identifies distinct OFC-subcortical pathways in macaques that support experience-based and inference-based value updating during adaptive decision-making.

This study disrupts the connection between the orbitofrontal cortex and rostromedial caudate nucleus in macaques using chemogenetics, showing it impairs reward-based motivational control of goal-directed actions.

This study evaluates orally delivered DCZ for chronic chemogenetic control of neuronal activity in macaques, showing prolonged effects and working memory impairments without desensitization.

This study uses chemogenetic methods to selectively silence prefronto-subcortical pathways in monkeys, revealing distinct roles in working memory and decision-making.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.