Masahiko Takada

This study maps the topographic and layer-specific projections from the primate anterior cingulate cortex to the amygdala, revealing distinct patterns for basal and accessory basal nuclei.

The paper maps the expression of three δ2-protocadherin genes in primate basal ganglia, showing complementary patterns that align with functional subdivisions and suggest molecular codes for parallel circuits.

This study identifies Scg2 as a secretory protein that promotes axon rewiring and motor recovery after stroke by enhancing axon growth through cAMP and S6 signaling.

The paper investigates how perceptual novelty and reward value interact in decision-making by identifying a neural pathway between the anterior ventral temporal cortex and orbitofrontal cortex.

This study uses retrograde optogenetics in macaques to show that FEF outputs to the superior colliculus are diverse but predominantly motor-related, supporting a visuomotor convergence model.

This study longitudinally assesses DREADD expression and efficacy in macaque monkeys using PET imaging and functional studies, showing peak expression at 60 days and sustained effects for two years.

This study demonstrates optogenetic modulation of peripheral sensory nerve activity in rats, showing induction and suppression of large-diameter afferents using ChR2 and eNpHR3.0.

This study identifies distinct OFC-subcortical pathways in macaques that support experience-based and inference-based value updating during adaptive decision-making.

The paper investigates how movement and reward expectancy modulate neural activity in different primate cortical areas during a conditioning task.

This study shows that two thalamostriatal systems in common marmosets have distinct roles in visual discrimination learning, with one affecting reversal learning and the other impacting task acquisition.

This paper develops an AI system to quantify social and pathophysiological behaviors in common marmosets using 3D pose estimation and unsupervised analysis.

The paper validates and optimizes the PSAM/PSEM chemogenetic system in nonhuman primates using multimodal imaging techniques to determine optimal agonist, dose, and timing for neuronal manipulation.

The paper develops a mosaic AAV vector that achieves high transgene expression and neuron specificity in primate brains, enabling effective chemogenetic manipulation and calcium imaging.

This study examines CST reorganization in macaques after partial spinal cord injury, showing axonal sprouting and re-direction in both rostral and caudal spinal segments contributing to recovery of finger dexterity.

This study disrupts the connection between the orbitofrontal cortex and rostromedial caudate nucleus in macaques using chemogenetics, showing it impairs reward-based motivational control of goal-directed actions.

The paper shows that amygdala neurons regulate dopamine neurons via disinhibition in rewarding environments, linking environmental context to basal ganglia circuits.

The paper identifies D1R-poor and D2R-poor zones in the mouse caudal striatum, showing they maintain conventional projection patterns despite imbalanced neuron distribution.

This study evaluates orally delivered DCZ for chronic chemogenetic control of neuronal activity in macaques, showing prolonged effects and working memory impairments without desensitization.

This study uses DREADD technology in common marmosets to show that chemogenetic activation of nigrostriatal dopamine neurons induces contralateral rotation behavior.

The paper shows that neurons in the primate caudate head encode temporally discounted value for delayed rewards, essential for motivation.

This study uses chemogenetic methods to selectively silence prefronto-subcortical pathways in monkeys, revealing distinct roles in working memory and decision-making.

The paper introduces MacaquePose, a dataset for markerless motion capture of macaques, showing neural network performance comparable to human-level pose estimation.

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

This study shows that the central amygdala (CeA) controls saccades and gaze direction based on emotional and social contexts through inactivation and optogenetic stimulation in monkeys.