Ken‐ichi Inoue

A prefrontal cortex-hypothalamus circuit for heart rate control in non-human primates

This paper identifies a prefrontal cortex-hypothalamus circuit that bidirectionally controls heart rate in non-human primates and shows its role in cognitive decision-making.

Social behaviours predict vocal turn-taking in common marmosets

The paper shows that social behaviors, not vocal features, predict vocal turn-taking in marmosets, highlighting multimodal coordination in primate communication.

Anterior cingulate cortex projections to the amygdala in primates: topographic and layer-specific organization underlying emotion and mood regulation

This study maps the topographic and layer-specific projections from the primate anterior cingulate cortex to the amygdala, revealing distinct patterns for basal and accessory basal nuclei.

Scg2 drives reorganization of the corticospinal circuit with spinal premotor interneurons to recover motor function after stroke

This study identifies Scg2 as a secretory protein that promotes axon rewiring and motor recovery after stroke by enhancing axon growth through cAMP and S6 signaling.

Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty

The paper investigates how perceptual novelty and reward value interact in decision-making by identifying a neural pathway between the anterior ventral temporal cortex and orbitofrontal cortex.

Retrograde Optogenetics Reveals Functional Convergence within a Corticotectal Pathway of Non-Human Primates

This study uses retrograde optogenetics in macaques to show that FEF outputs to the superior colliculus are diverse but predominantly motor-related, supporting a visuomotor convergence model.

Longitudinal assessment of DREADD expression and efficacy in the monkey brain

This study longitudinally assesses DREADD expression and efficacy in macaque monkeys using PET imaging and functional studies, showing peak expression at 60 days and sustained effects for two years.

Dissecting Medullary Raphe Neurons Regulating Multiple Thermogenic Pathways

This paper identifies RPa-vGluT3 neurons as critical regulators of thermogenesis by coordinating sympathetic and somatic motor outputs to increase body temperature.

Bidirectional Optogenetic Modulations of Peripheral Sensory Nerve Activity: Induction vs. Suppression through Channelrhodopsin and Halorhodopsin

This study demonstrates optogenetic modulation of peripheral sensory nerve activity in rats, showing induction and suppression of large-diameter afferents using ChR2 and eNpHR3.0.

Distinct roles of monkey OFC-subcortical pathways in adaptive behavior

This study identifies distinct OFC-subcortical pathways in macaques that support experience-based and inference-based value updating during adaptive decision-making.

Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex

The paper investigates how movement and reward expectancy modulate neural activity in different primate cortical areas during a conditioning task.

Distinct roles of two thalamostriatal systems in learning processes of visual discrimination in common marmosets

This study shows that two thalamostriatal systems in common marmosets have distinct roles in visual discrimination learning, with one affecting reversal learning and the other impacting task acquisition.

Establishing an AI-based evaluation system that quantifies social/pathophysiological behaviors of common marmosets

This paper develops an AI system to quantify social and pathophysiological behaviors in common marmosets using 3D pose estimation and unsupervised analysis.

Multimodal imaging for validation and optimization of ion channel-based chemogenetics in nonhuman primates

The paper validates and optimizes the PSAM/PSEM chemogenetic system in nonhuman primates using multimodal imaging techniques to determine optimal agonist, dose, and timing for neuronal manipulation.

A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain

The paper develops a mosaic AAV vector that achieves high transgene expression and neuron specificity in primate brains, enabling effective chemogenetic manipulation and calcium imaging.

Chemogenetic disconnection between the orbitofrontal cortex and the rostromedial caudate nucleus disrupts motivational control of goal-directed action

This study disrupts the connection between the orbitofrontal cortex and rostromedial caudate nucleus in macaques using chemogenetics, showing it impairs reward-based motivational control of goal-directed actions.

Primate dopamine neurons activated in rewarding environment by tonic disinhibition from amygdala

The paper shows that amygdala neurons regulate dopamine neurons via disinhibition in rewarding environments, linking environmental context to basal ganglia circuits.

Conservation of the direct and indirect pathways dichotomy in mouse caudal striatum with uneven distribution of dopamine receptor D1- and D2-expressing neurons

The paper identifies D1R-poor and D2R-poor zones in the mouse caudal striatum, showing they maintain conventional projection patterns despite imbalanced neuron distribution.

Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaques

This study evaluates orally delivered DCZ for chronic chemogenetic control of neuronal activity in macaques, showing prolonged effects and working memory impairments without desensitization.

Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets

This study uses DREADD technology in common marmosets to show that chemogenetic activation of nigrostriatal dopamine neurons induces contralateral rotation behavior.

Single caudate neurons encode temporally discounted value for formulating motivation for action

The paper shows that neurons in the primate caudate head encode temporally discounted value for delayed rewards, essential for motivation.

Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making

This study uses chemogenetic methods to selectively silence prefronto-subcortical pathways in monkeys, revealing distinct roles in working memory and decision-making.

MacaquePose: A novel 'in the wild' macaque monkey pose dataset for markerless motion capture

The paper introduces MacaquePose, a dataset for markerless motion capture of macaques, showing neural network performance comparable to human-level pose estimation.

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

This paper introduces deschloroclozapine (DCZ), a potent and selective DREADD agonist that rapidly modulates neuronal activity and behavior in mice and monkeys.

Amygdala controls saccade and gaze physically, motivationally, and socially

This study shows that the central amygdala (CeA) controls saccades and gaze direction based on emotional and social contexts through inactivation and optogenetic stimulation in monkeys.

Deletion of class II ARF causes essential tremors through Nav1.6 traffic impairment

This study shows that deletion of class II ARF causes essential tremors by impairing Nav1.6 trafficking to Purkinje cell axon initial segments.