Kaspar Kevvai

This paper improves the microbial synthesis of benzylisoquinoline alkaloids in yeast by using human monoamine oxidase A to increase selectivity and yield of (S)-reticuline and its derivatives.

The paper screens non-conventional yeasts for organic acid tolerance and engineers Pichia occidentalis to produce cis,cis-muconic acid with improved metrics compared to Saccharomyces cerevisiae.

This paper describes a yeast platform that significantly increases the production of tetrahydroisoquinoline alkaloids, enabling the synthesis of natural and unnatural derivatives.