Hans M. Morreau

Smad4 and TGF-β1 dependent gene expression biomarkers in conditional intestinal adenoma, organoids and colorectal cancer.

The paper identifies Smad4 and TGF-β1 dependent gene expression biomarkers in intestinal adenomas and colorectal cancer using murine models and RNA sequencing.

Prevalence and consequences of APC mosaicism in patients with colorectal adenomas

The paper identifies APC mosaicism in patients with colorectal adenomas, finds higher prevalence in those meeting hereditary polyposis guidelines, and recommends targeted testing and surveillance.

Immunological profiles in Lynch syndrome colorectal cancers are not specific to mismatch repair gene defects

The paper examines immune profiles in Lynch syndrome colorectal cancers across different MMR gene defects and finds no significant differences in immunogenic features.

Lower degree of microsatellite instability in colorectal carcinomas from MSH6-associated Lynch syndrome patients

The paper compares microsatellite instability in colorectal carcinomas from MSH6-associated Lynch syndrome patients to other MMR-deficient groups and sporadic MSI CRCs, finding lower MSI in MSH6-mutated tumors.