Charlotte J. Imianowski

A Reference Landscape of Regulatory T Cell States in Mice

The paper defines a unified framework for Treg heterogeneity using a joint RNA-protein model, identifying eight conserved clusters across tissues and conditions.

immgenT: A Comprehensive Reference of Convergent T-cell States in the Mouse

immgenT creates a comprehensive T-cell molecular atlas across mouse organs and disease states, identifying 8 lineages and 107 clusters using deep generative models and integrating external datasets.

Genomic Specificity of Anti-TCR mAbs determined by single-cell RNAseq

The paper identifies TCR-V gene usage patterns in T cells sorted by anti-TCR mAbs using single-cell RNAseq and finds enriched ERV1-family LTR expression in specific TRBV regions.

Expansion of mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis

The paper examines T cell changes in mammary glands during pregnancy and lactation, finding an expansion of T effector cells and similarities to intestinal T cells.

Smad4 and TGF-β1 dependent gene expression biomarkers in conditional intestinal adenoma, organoids and colorectal cancer.

The paper identifies Smad4 and TGF-β1 dependent gene expression biomarkers in intestinal adenomas and colorectal cancer using murine models and RNA sequencing.

Hexa-acylated lipopolysaccharides from the gut microbiota enhance cancer immunotherapy responses

The paper identifies hexa-acylated lipopolysaccharides from the gut microbiome as a biomarker and enhancer of anti-PD-1 immunotherapy responses in melanoma patients.